5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that plays a central role in NAD+ metabolism, cellular energy regulation, and adipogenesis. It has emerged as one of the most significant compounds in metabolic and longevity research over the past decade, with a growing body of preclinical literature exploring its role in reversing metabolic dysfunction at the cellular level.
NNMT Inhibition and NAD+ Research
NNMT consumes S-adenosylmethionine (SAM) and converts nicotinamide into 1-methylnicotinamide — a process that depletes cellular NAD+ precursor pools and reduces methyl group availability. 5-Amino-1MQ has been studied for its potent and selective NNMT inhibition, with research exploring how blocking this pathway elevates intracellular NAD+ levels, restores sirtuin activity, and improves mitochondrial function in metabolically compromised cell models.
Adipogenesis and Fat Cell Research
One of the most studied aspects of 5-Amino-1MQ is its role in adipocyte regulation. Research has explored its ability to reduce fat cell size, inhibit adipogenic differentiation, and modulate lipid storage pathways — making it a significant compound in obesity biology and metabolic disease research models.
Sirtuin and Longevity Pathway Research
By elevating NAD+ availability, 5-Amino-1MQ has been studied for its downstream activation of sirtuins — particularly SIRT1 and SIRT3 — which are key regulators of cellular ageing, mitochondrial biogenesis, and stress resistance. Research has explored its potential role in longevity signalling and age-related metabolic decline models.
Mitochondrial Function Research
Studies have explored 5-Amino-1MQ's role in improving mitochondrial membrane potential, ATP synthesis efficiency, and oxidative phosphorylation in metabolically stressed cell models. Its ability to restore mitochondrial function through NAD+ replenishment makes it a key compound in mitochondrial biology research.
Muscle and Metabolic Research
Emerging research has explored 5-Amino-1MQ's role in skeletal muscle metabolism, including its effects on glucose uptake, insulin sensitivity, and muscle fibre energy utilisation — making it relevant to both metabolic dysfunction and exercise biology research protocols.
Each vial contains 10mg of lyophilized 5-Amino-1MQ with ≥99% purity, verified by third-party HPLC testing.
Intended strictly for research and laboratory use only. Not for human consumption.
